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Qc1

Qc1是苏氨酸脱氢酶（TDH）的抑制剂，可用于有关代谢性疾病的研究。

CAS号

403718-45-6

分子式

C23H16F3N3O2S

主要靶点

Dehydrogenase

仅限科研使用

Cat No : CM11614

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Synonyms

Qc 1

验证数据展示

  • CAS No.: 403718-45-6

    Qc1
    CAS#: 403718-45-6

产品信息

Qc1 is an inhibitor of threonine dehydrogenase (TDH) inhibitor and can be used in studies about metabolic diseases.

CAS号 403718-45-6
分子式 C23H16F3N3O2S
主要靶点 Dehydrogenase
主要通路 代谢
分子量 455.45
纯度 100.00%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Qc 1

体外活性

Qc1 prevents threonine dehydrogenase from catabolizing threonine into acetyl-CoA and glycine and blocks the charging of tetrahydrofolate(THF). In ES cells, Qc1 (10 μM) increases autophagic activity[2].

溶解度

DMSO:20 mg/ml (43.9 mM)

参考文献

1.Alexander PB, et al. Targeted killing of a mammalian cell based upon its specialized metabolic state. Proc Natl Acad Sci U S A. 2011;108(38):15828-15833.
2.Wang J, et al. Metabolic specialization of mouse embryonic stem cells. Cold Spring Harb Symp Quant Biol. 2011;76:183-193.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2