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Pumaprazole

CAS号

158364-59-1

分子式

C19H22N4O2

主要靶点

Proton pump

仅限科研使用

Cat No : CM16712

Print datasheet

Synonyms

inhibit|BY 841|BY841|BY-841|普马拉唑|Inhibitor|Pumaprazole|Protonpump|Proton Pump|Proton pump|proton pump

验证数据展示

  • CAS No.: 158364-59-1

    Pumaprazole
    CAS#: 158364-59-1

产品信息

CAS号 158364-59-1
分子式 C19H22N4O2
主要靶点 Proton pump
主要通路 离子通道
分子量 338.4
纯度 99.6%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 inhibit|BY 841|BY841|BY-841|普马拉唑|Inhibitor|Pumaprazole|Protonpump|Proton Pump|Proton pump|proton pump

体内活性

Pumaprazole shows identical ID50 values on day 1 (11 μmol/kg, 95% confidence limits of 5 and 23), and on day 7 (10 μmol/kg, 95% confidence limits of 4 and 23) of a repeated dose study in this model. Basal acid secretion in the Ghosh-Schild rat is inhibited by Pumaprazole with a higher efficacy compared to ranitidine. The lower dose of Pumaprazole (27 μmol/kg) rapidly elevates luminal pH up to almost neutrality, the higher dose (54 μmol/kg) further prolongs this pH-elevating effect[1].

溶解度

DMSO:55 mg/ml (162.53 mM)

参考文献

1.Kromer W, et al. Animal pharmacology of reversible antagonism of the gastric acid pump, compared to standard antisecretory principles. Pharmacology. 2000 May;60(4):179-87.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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C1   V1   C2   V2