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Procyanidin B2

CAS号

29106-49-8

分子式

C30H26O12

主要靶点

Reactive Oxygen Species|NOD

仅限科研使用

Cat No : CM00462

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Synonyms

inhibit|Inhibitor|NLRP3|Reactive Oxygen Species|ReactiveOxygenSpecies|Procyanidin B2|Procyanidin B-2|Procyanidin B 2|Proanthocyanidin B 2|Proanthocyanidin B2|Proanthocyanidin B-2|原花青素 B2

验证数据展示

  • CAS No.: 29106-49-8

    Procyanidin B2
    CAS#: 29106-49-8

产品信息

CAS号 29106-49-8
分子式 C30H26O12
主要靶点 Reactive Oxygen Species|NOD
主要通路 免疫与炎症|NF-κB 信号通路|免疫与炎症|代谢|NF-κB 信号通路
分子量 578.52
纯度 99.21%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 inhibit|Inhibitor|NLRP3|Reactive Oxygen Species|ReactiveOxygenSpecies|Procyanidin B2|Procyanidin B-2|Procyanidin B 2|Proanthocyanidin B 2|Proanthocyanidin B2|Proanthocyanidin B-2|原花青素 B2

体内活性

肉桂中的Procyanidin B2抑制了糖尿病大鼠肾脏中AGEs的积累，并改善了AGEs介导的DN[2]的病理过程。

体外活性

Procyanidin B2 通过与 H2O2 和金属离子的相互作用, 表现出抗氧化和促氧化的特性[1]。

溶解度

DMSO:50 mg/mL (86.43 mM)

动物实验

Streptozotocin-induced diabetic rats were fed with either 3% cinnamon or 0.002% Procyanidin B2(PCB2)-fraction in diet for 12weeks. Biochemical analysis of blood and urine was performed at the end of experiment. Evaluation of glomerular markers that serve as indicators of renal function was done by immunohistochemistry, immunoblotting and qRT-PCR. Supplementation of diabetic rats with cinnamon and PCB2-fraction prevented glycation mediated RBC-IgG cross-links and HbA1c accumulation in diabetes rats. Cinnamon and PCB2-fraction also inhibited the accumulation of N-carboxy methyl lysine (CML), a prominent AGE in diabetic kidney[2].

参考文献

1.Sakano K , Mizutani M , Murata M , et al. Procyanidin B2 has anti- and pro-oxidant effects on metal-mediated DNA damage[J]. Free Radical Biology & Medicine, 2005, 39(8):1041-1049.
2.Muthenna P , Raghu G , Kumar P A , et al. Effect of cinnamon and its procyanidin-B2 enriched fraction on diabetic nephropathy in rats[J]. Chemico-Biological Interactions, 2014, 222:68-76.

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