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Prochlorperazine Maleate

CAS号

84-02-6

分子式

C28H32ClN3O8S

主要靶点

Dopamine Receptor

仅限科研使用

Cat No : CM03777

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Synonyms

D2|Dopamine Receptor|DopamineReceptor|Compazine|Capazine|Stemetil|丙氯拉嗪|Prochlorperazine|Prochlorperazine Dimaleate|Prochlorperazine dimaleate salt|Prochlorperazine Maleate|Prochlorperazine maleate salt

验证数据展示

  • CAS No.: 84-02-6

    Prochlorperazine Maleate
    CAS#: 84-02-6

产品信息

CAS号 84-02-6
分子式 C28H32ClN3O8S
主要靶点 Dopamine Receptor
主要通路 G 蛋白偶联受体|神经科学
分子量 606.09
纯度 99.99%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 D2|Dopamine Receptor|DopamineReceptor|Compazine|Capazine|Stemetil|丙氯拉嗪|Prochlorperazine|Prochlorperazine Dimaleate|Prochlorperazine dimaleate salt|Prochlorperazine Maleate|Prochlorperazine maleate salt

体内活性

Prochlorperazine 在小鼠中可以诱导抗痛觉效应。经Prochlorperazine处理后的小鼠在转棒试验中显示出完整的运动协调能力，保持了正常的自发移动性和通过孔板测试显示的探索行为。[1]。

体外活性

Prochlorperazine 通过下调cyclin E2表达抑制对他莫昔芬(tamoxifen)有抗性的MCF-7细胞的增殖。Prochlorperazine 具有影响雌激素受体(estrogen receptor, ER)功能的潜力，且可能改变内分泌治疗的反应[2]。

溶解度

H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:2 mg/mL (3.3 mM);DMSO:45 mg/mL (74.25 mM)

细胞实验

Cells are treated 5 μM of prochlorperazine for 5 days and cell proliferation is measured by methylene blue staining or for 2 days and cyclin E2 mRNA levels are measured by qPCR.(Only for Reference)

参考文献

1.Ghelardini C, et al. Pharmacol Res. 20014, 50(3):351-358.
2.Huang L, et al. PLoS One. 2011, 6(7):e22274.
3.Dong L, Shen S, Chen W, et al. Discovery of Novel Inhibitors Targeting Human O-GlcNAcase: Docking-Based Virtual Screening, Biological Evaluation, Structural Modification, and Molecular Dynamics Simulation[J]. Journal of chemical information and modeling. 2019, 59(10): 4374-4382.

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