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Procaine hydrochloride

CAS号

51-05-8

分子式

C13H20N2O2·HCl

主要靶点

DNA/RNA Synthesis|AChR|NMDAR|Histone Demethylase|Sodium Channel|5-HT Receptor

仅限科研使用

Cat No : CM00032

Print datasheet

Synonyms

5HTReceptor|5-HT3|5HT Receptor|duration|DNA Synthesis|DNA/RNA Synthesis|DNASynthesis|inhibit|Histone Demethylase|HistoneDemethylase|onset|NMDA receptor|Novocaine HCl|nAChR|RNA Synthesis|RNASynthesis|Procaine|Procaine HCl|Procaine Hydrochloride|Procaine hydrochloride|Inhibitor|multiple|SodiumChannel|Sodium channel|Sodium Channel|targets|盐酸普鲁卡因

验证数据展示

  • CAS No.: 51-05-8

    Procaine hydrochloride
    CAS#: 51-05-8

产品信息

CAS号 51-05-8
分子式 C13H20N2O2·HCl
主要靶点 DNA/RNA Synthesis|AChR|NMDAR|Histone Demethylase|Sodium Channel|5-HT Receptor
主要通路 表观遗传|神经科学|G 蛋白偶联受体|DNA 损伤和修复|离子通道|细胞周期|神经科学|神经科学
分子量 272.77
纯度 100.00%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 5HTReceptor|5-HT3|5HT Receptor|duration|DNA Synthesis|DNA/RNA Synthesis|DNASynthesis|inhibit|Histone Demethylase|HistoneDemethylase|onset|NMDA receptor|Novocaine HCl|nAChR|RNA Synthesis|RNASynthesis|Procaine|Procaine HCl|Procaine Hydrochloride|Procaine hydrochloride|Inhibitor|multiple|SodiumChannel|Sodium channel|Sodium Channel|targets|盐酸普鲁卡因

靶点活性

5-HT3:1.7 μM(Kd)|Na+ channel:60 μM|nAChR:45.5 μM|NMDAR:0.296 mM

体内活性

Procaine具有结合或拮抗烟碱型乙酰胆碱受体和5-羟色胺受体-离子通道复合体与N-甲基-D-天冬氨酸受体的功能。Procaine主要通过抑制钠离子进而影响外周神经的神经元细胞膜上电压门控钠离子通道的内流来发挥作用。当钠离子内流被中断时,动作电位被阻断,信号传导也因此受到抑制。有研究认为受体部位是位于钠通道的细胞质(内部)部分。

体外活性

在清醒的猫体内,Procaine（15 mg/kg）增加杏仁核腹侧海马体,腹内侧下丘脑,伏隔核和颞叶新皮质的细胞活性.Procaine是边缘系统细胞的兴奋剂.Procaine促进诱发的刺激活性从杏仁核到腹内侧下丘脑的传导.

溶解度

H2O:50 mg/mL (183.3 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:55 mg/mL (201.64 mM)

参考文献

1.Br?u ME ME, et al. Anesth Analg, 1998, 87(4), 885-889.
2.Hahnenkamp K, et al. Br J Anaesth, 2006, 96(1), 77-87.
3.Wang H, et al. Eur J Pharmacol, 2010, 630(1-3), 29-33.
4.Fan P, et al. Neuropharmacology, 1994, 33(12), 1573-1579.
5.Zahradníková A, et al. Biophys J. 1993 Apr;64(4):1991-12003.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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