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(E/Z)-Polydatin

(E/Z)-Polydatin (Polydatin) 是从虎杖的根和根茎中分离得到的一种单晶化合物。它具有抗血小板聚集、心脏保护作用、抗低密度脂蛋白 (LDL) 氧化作用、抗炎和免疫调节功能。

CAS号

65914-17-2

分子式

C20H22O8

主要靶点

Phospholipase

仅限科研使用

Cat No : CM00451

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Synonyms

Polydatin|(E/Z)-Piceid|云杉新甙|(E/Z)-虎杖苷

验证数据展示

  • CAS No.: 65914-17-2

    (E/Z)-Polydatin
    CAS#: 65914-17-2

产品信息

(E/Z)-Polydatin, is a natural precursor and glycoside form of resveratrol with a monocrystalline structure. While it is isolated from the bark of Picea sitchensis or Polygonum cuspidatum, Polydatin may be detected in grape, peanut, hop cones, red wines, hop pellets, cocoa-containing products, chocolate products and many daily diets. Polydatin possesses anti-inflammatory, immunoregulatory, anti-oxidative and anti-tumor activities. It is shown to mediate a cytotoxic action on colorectal cancer cells by inducing cell arrest and apoptosis.

CAS号 65914-17-2
分子式 C20H22O8
主要靶点 Phospholipase
主要通路 代谢
分子量 390.39
纯度 100.00%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Polydatin|(E/Z)-Piceid|云杉新甙|(E/Z)-虎杖苷

体内活性

Polydatin是一种PLA2抑制剂,可使sPLA2-IIA mRNA表达和磷脂酶A2活性降低,还可使Clara细胞分泌蛋白的表达增加,从而减轻脂多糖诱导的肺部损伤。

体外活性

在盲肠结扎穿孔诱导的败血症小鼠体内,Polydatin（15/45/100 mg/kg）可抑制CLP诱导的血清TNF-α和IL-6的产生、肺环氧合酶-2和诱导型NO合酶异构体的蛋白质表达及NF-κB活化,从而剂量依赖性降低败血症造成的死亡率和肺损伤.小鼠中Polydatin的LD50为1 g/kg（i.p.）.

溶解度

DMSO:72 mg/mL (184.4 mM),Ethanol:<1 mg/mL,H2O:<1 mg/mL

参考文献

1.Shiyu S, et al. BMC Cell Biol, 2011, 25, 12:31.
2.Li XH, et al. Mediators Inflamm, 2013, 2013, 354087.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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C1   V1   C2   V2