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Pim1/AKK1-IN-1

Pim1/AKK1-IN-1 (LKB1/AAK1 dual inhibitor) 是多种酶抑制剂，能够作用于Pim1、AKK1、MST2 和 LKB1，Kd 值分别为 35、53、75 和 380 nM，还抑制 MPSK1 和 TNIK。

CAS号

1093222-27-5

分子式

C20H13N5O

主要靶点

Hippo pathway|Pim

仅限科研使用

Cat No : CM17337

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Synonyms

LKB1/AAK1 dual inhibitor|MDK-2275

验证数据展示

  • CAS No.: 1093222-27-5

    Pim1/AKK1-IN-1
    CAS#: 1093222-27-5

产品信息

Pim1/AKK1-IN-1 is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK.

CAS号 1093222-27-5
分子式 C20H13N5O
主要靶点 Hippo pathway|Pim
主要通路 干细胞|表观遗传|JAK/STAT信号通路
分子量 339.35
纯度 98.69%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 LKB1/AAK1 dual inhibitor|MDK-2275

靶点活性

AKK1:53 nM (Kd)|Pim1:35 nM (Kd)|MST2:75 nM (Kd)|LKB1:380 nM (Kd)

溶解度

DMSO:15 mg/mL (44.2 mM)

参考文献

1.Bamborough P, et al. Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. J Med Chem. 2008 Dec 25;51(24):7898-914.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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C1   V1   C2   V2