Recombinant Pig CXCL8/IL-8 protein (rFc Tag)
种属
Pig
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Pig CXCL8 protein Ala26-Gln103 (Accession# P26894) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 396880 |
| 蛋白编号 | P26894 |
| 预测分子量 | 35.4 KDa |
| SDS-PAGE | 35-45 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Interleukin 8 (IL-8), also known as CXCL8, which is a member of the CXC chemokine family. This chemokine is secreted by a variety of cell types including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, and various tumor cell lines in response to inflammatory stimuli. IL-8 has two primary functions. It induces chemotaxis in target cells, primarily neutrophils but also other granulocytes, causing them to migrate toward the site of infection. IL-8 also induces phagocytosis once they have arrived. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. IL-8 is also known to be a potent promoter of angiogenesis. IL-8 has been associated with tumor angiogenesis, metastasis, and poor prognosis in breast cancer. IL-8 may present a novel therapeutic target for estrogen driven breast carcinogenesis and tumor progression.
参考文献:
1. Wolff B. et al., 1998. J Exp Med. 188: 1757-1762. 2. Utgaard JO. et al., 1998. J Exp Med. 188: 1751-1756. 3. Modi WS. Et al., 1990. Hum Genet. 84: 185-187. 4. "Entrez Gene: IL8 interleukin 8". 5. Bendrik C. et al. 2009. J Immunol. 182(1): 371-378.
