Phospho-TAU (Thr181) Polyclonal antibody

Phospho-TAU (Thr181) Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, ELISA and More (1)

Conjugate

Unconjugated

Cat no : 28866-1-AP

Print datasheet

Synonyms

MAPT, TAU, Paired helical filament tau, Microtubule-associated protein tau, MAPTL



经过测试的应用

Positive WB detected inPDGF treated SH-SY5Y cells

推荐稀释比

ApplicationDilution
Western Blot (WB)WB : 1:500-1:1000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

28866-1-AP targets Phospho-TAU (Thr181) in WB, IF, ELISA applications and shows reactivity with human, mouse samples.

Tested Applications WB, ELISA Application Description
Cited ApplicationsWB, IF
Tested Reactivity human, mouse
Cited Reactivityhuman, mouse
Immunogen Peptide 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name microtubule-associated protein tau
Synonyms MAPT, TAU, Paired helical filament tau, Microtubule-associated protein tau, MAPTL
Calculated Molecular Weight 37-46, 79-81 kDa
Observed Molecular Weight50-80 kDa
GenBank Accession NumberBC000558
Gene Symbol TAU
Gene ID (NCBI) 4137
RRIDAB_2881222
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP10636
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

Tau (tubulin-associated unit) is a microtubule-associated protein (also known as MAPT), expressed mainly in neurons of the central nervous system. Its primary function is to modulate microtubule dynamics for maintaining axonal cytoskeleton. The Tau protein has six isoforms produced from a single gene through alternative RNA splicing. Isoforms differ in number of inserts at the N-terminal half and the number of repeats at the C-terminal half (3 repeat-3R; 4 repeat-4R). Tau is hyperphosphorylated during aging and in age-related neurodegenerative diseases such as Alzheimer's disease (AD) and fronto-temporal dementia. Hyperphosphorylation of Tau leads to the formation of neurofibrillary tangles (NFT) in the neurons and glia cells, which is one of the hallmarks of AD.

实验方案

Product Specific Protocols
WB protocol for Phospho-TAU (Thr181) antibody 28866-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle
humanWB

Biochim Biophys Acta Mol Basis Dis

Apolipoprotein E ε4 triggers neurotoxicity via cholesterol accumulation, acetylcholine dyshomeostasis, and PKCε mislocalization in cholinergic neuronal cells

Authors - Rebecca Piccarducci
mouseWB

Neural Plast

Treatment Combining Focused Ultrasound with Gastrodin Alleviates Memory Deficit and Neuropathology in an Alzheimer's Disease-Like Experimental Mouse Model.

Authors - Kaixuan Luo
humanWB

Neurotoxicology

Protective mechanism of gold nanoparticles on human neural stem cells injured by β-amyloid protein through miR-21-5p/SOCS6 pathway

Authors - Guoqing Wang
mouseWB

ACS Biomater Sci Eng

RVG29 Peptide-Modified Exosomes Loaded with Mir-133b Mediate the RhoA-ROCK Pathway to Improve Motor and Neurological Symptoms in Parkinson's Disease

Authors - Peng Jiang
human

ACS Chem Neurosci

First in Class Dual Non-ATP-Competitive Glycogen Synthase Kinase 3β/Histone Deacetylase Inhibitors as a Potential Therapeutic to Treat Alzheimer's Disease

Authors - Alan Santini
mouseWB,IF

Eur J Pharmacol

Cerebroprotein hydrolysate-I ameliorates cognitive dysfunction in APP/PS1 mice by inhibiting ferroptosis via the p53/SAT1/ALOX15 signalling pathway

Authors - Xin Ren