• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

Phenylbiguanide

CAS号

102-02-3

分子式

C8H11N5

主要靶点

5-HT Receptor

仅限科研使用

Cat No : CM02041

Print datasheet

Synonyms

1-苯基双胍|1-Phenylbiguanide|5-HT Receptor|5HT Receptor|5-hydroxytryptamine Receptor|5HTReceptor|5-HT3|inhibit|Serotonin Receptor|Phenylbiguanide|PBG|N-Phenylbiguanide|Inhibitor

验证数据展示

  • CAS No.: 102-02-3

    Phenylbiguanide
    CAS#: 102-02-3

产品信息

CAS号 102-02-3
分子式 C8H11N5
主要靶点 5-HT Receptor
主要通路 G 蛋白偶联受体|神经科学
分子量 177.21
纯度 99.87%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 1-苯基双胍|1-Phenylbiguanide|5-HT Receptor|5HT Receptor|5-hydroxytryptamine Receptor|5HTReceptor|5-HT3|inhibit|Serotonin Receptor|Phenylbiguanide|PBG|N-Phenylbiguanide|Inhibitor

靶点活性

5-HT3:3 μM (EC50)

体内活性

Phenylbiguanide (PBG) 是一种已知能够刺激心肺传入C-纤维的化合物。在麻醉的小鼠中，PBG 被注射入心脏的右心房，并在中央神经系统的特定区域内绘制了c-Fos表达图谱。PBG 的心房内注射会产生反射性心肺反应，包括显著的心动过缓和呼吸抑制[1]。

溶解度

DMSO:150 mg/mL (846.45 mM)

参考文献

1.de Vries A, Paton JF, Lightman SL,et al.Characterisation of c-Fos expression in the central nervous system of mice following right atrial injections of the 5-HT3 receptor agonist phenylbiguanide[J].Auton Neurosci. 2005 Dec 30;123(1-2):62-75.
2.Benuck M , Reith M E A . Dopamine releasing effect of phenylbiguanide in rat striatal slices[J]. Archiv für Experimentelle Pathologie und Pharmakologie, 1992, 345(6):666-672.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2