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Perhexiline maleate

Perhexiline maleate 是一种口服活性的 CPT1和 CPT2抑制剂，可降低脂肪酸的代谢。Perhexiline maleate 对大鼠心脏和肝脏CPT 1的IC50值分别为77 和 148 μM。

CAS号

6724-53-4

分子式

C23H39NO4

主要靶点

Mitochondrial Metabolism|Others

仅限科研使用

Cat No : CM06735

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Synonyms

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  • CAS No.: 6724-53-4

    Perhexiline maleate
    CAS#: 6724-53-4

产品信息

Perhexiline maleate is a potent inhibitor of carnitine palmitoyltransferase 1 (CPT 1) (rat heart and liver CPT 1 with IC50s of 77 and 148 μM , respectively).

CAS号 6724-53-4
分子式 C23H39NO4
主要靶点 Mitochondrial Metabolism|Others
主要通路 代谢|其他
分子量 393.56
纯度 ， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

Rat heart CPT 1:77 μM (IC50)|Rat liver CPT 1:148 μM (IC50)

体内活性

The co-administration of Perhexiline and cisplatin yields a clear enhancement of antitumor effects, resulting in a significantly improved progression-free survival as compared with mice treated with DMSO.

体外活性

Perhexiline treatment increases the susceptibility of NB cells to antiblastic treatments. Co-administration of Perhexiline maleate potentiates the efficacy of cisplatin to reduce the in vitro clonogenic potential of NB cells[2].

溶解度

DMSO:27.5 mg/mL (69.87 mM)

参考文献

1.Kennedy JA, et al. Inhibition of carnitine palmitoyltransferase-1 in rat heart and liver by Perhexiline and amiodarone. Biochem Pharmacol. 1996 Jul 26;52(2):273-80.
2.Vella S, et al. Perhexiline maleate enhances antitumor efficacy of cisplatin in neuroblastoma by inducing over-expression of NDM29 ncRNA. Sci Rep. 2015 Dec 17;5:18144.

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