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Pentostatin

CAS号

53910-25-1

分子式

C11H16N4O4

主要靶点

Adenosine deaminase|Adenosine Receptor

仅限科研使用

Cat No : CM00429

Print datasheet

Synonyms

Covidarabine|Deoxycoformycin|Adenosinedeaminase|AdenosineReceptor|Adenosine receptor|Adenosine deaminase|Adenosine Deaminase|Adenosine Receptor|CI 825|CI825|CI-825|喷司他丁|Nipent|Pentostatin|Inhibitor|inhibit

验证数据展示

  • CAS No.: 53910-25-1

    Pentostatin
    CAS#: 53910-25-1

产品信息

CAS号 53910-25-1
分子式 C11H16N4O4
主要靶点 Adenosine deaminase|Adenosine Receptor
主要通路 G 蛋白偶联受体|神经科学|代谢
分子量 268.27
纯度 99.89%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Covidarabine|Deoxycoformycin|Adenosinedeaminase|AdenosineReceptor|Adenosine receptor|Adenosine deaminase|Adenosine Deaminase|Adenosine Receptor|CI 825|CI825|CI-825|喷司他丁|Nipent|Pentostatin|Inhibitor|inhibit

靶点活性

Adenosine deaminase:2.5 pM (Ki)

溶解度

DMSO:50 mg/mL (186.38 mM)

参考文献

1.Nabhan, et Al. Purine nucleoside analogues and combination therapies in B-cell chronic lymphocytic leukemia: dawn of a new era. Leukemia Res. 28 429.
2.Klohs Klohs WD., et al. Pentostatin: future directions. Pharmacol.Rev. 44 459.
3.Reynolds C., et al. Richards DA, Robbins GJ, Vellek M, Boehm KA, Zhan F, Asmar L.A Phase III trial of fludarabine, cyclophosphamide, and rituximab vs. pentostatin, cyclophosphamide, and rituximab in B-cell chronic lymphocytic leukemia.Invest New Drugs. 2012 Jun;30(3):1232-40. Epub 2011 Sep 16.
4.Grever MR.Hairy cell leukemia: a successful model for experimental therapeutics--pentostatin and new ideas.Leuk Lymphoma. 2011 Jun;52 Suppl 2:25-8.
5.Dearden CE, Else M, Catovsky D.Long-term results for pentostatin and cladribine treatment of hairy cell leukemia.Leuk Lymphoma. 2011 Jun;52 Suppl 2:21-4.
6.Wang J, Liu Y, Liu Y, et al. Time-resolved protein activation by proximal decaging in living systems[J]. Nature. 2019 May;569(7757):509-513.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2