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验证数据展示

  • IHC staining of human lymphoma using 11783-1-AP (same clone as 11783-1-PBS)

    IHC staining of human lymphoma using 11783-1-AP (same clone as 11783-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lymphoma tissue slide using 11783-1-AP (PTPN22 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11783-1-PBS in a different storage buffer formulation.

  • WB analysis using 11783-1-AP (same clone as 11783-1-PBS)

    WB analysis using 11783-1-AP (same clone as 11783-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 11783-1-AP (PTPN22 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11783-1-PBS in a different storage buffer formulation.

  • IP experiment of Jurkat using 11783-1-AP (same clone as 11783-1-PBS)

    IP experiment of Jurkat using 11783-1-AP (same clone as 11783-1-PBS)

    IP result of anti-PTPN22 (IP:11783-1-AP, 4ug; Detection:11783-1-AP 1:300) with Jurkat cells lysate 3080ug. This data was developed using the same antibody clone with 11783-1-PBS in a different storage buffer formulation.

PTPN22 Polyclonal antibody, PBS Only

PTPN22 Polyclonal Antibody for WB, IHC, IP, Indirect ELISA
Cat No. 11783-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, IP, Indirect ELISA

别名

EC:3.1.3.48, Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP, LyP, LYP1, LYP2

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

11783-1-PBS targets PTPN22 in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, IP, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag2397

Product name: Recombinant human PTPN22 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-179 aa of BC017785

Sequence: MDQREILQKFLDEAQSKKITKEEFANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKEAEKRKSDYIIRTLKVKFNSVSVILAHQTSLQNLFSQITPAHF

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
别名 EC:3.1.3.48, Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP, LyP, LYP1, LYP2
计算分子量 82 kDa, 92 kDa
观测分子量 100-110 kDa
GenBank蛋白编号BC017785
基因名称 PTPN22
Gene ID (NCBI) 26191
RRIDAB_2173378
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9Y2R2
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

PTPN22(Tyrosine-protein phosphatase non-receptor type 22) is also named as LyP,PEP,PTPN8.It belongs to the protein-tyrosine phosphatase family and non-receptor class 4 subfamily.It acts as negative regulator of T-cell receptor (TCR) signaling.Defects in PTPN22 are a cause of susceptibility to systemic lupus erythematosus (SLE). It has some isoforms produced by alternative splicing with calculated molecular mass of 79-92 kDa, and apparent molecular mass of 100-110 kDa.

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