• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

PTP1B-IN-2

CAS号

1919853-46-5

分子式

C34H36N2O9S2

主要靶点

Phosphatase

仅限科研使用

Cat No : CM05910

Print datasheet

Synonyms

inhibit|Inhibitor|Phosphatase|PTP1B|PTP1B IN 2|PTP1BIN2|PTP-1B-IN-2|PTP1B-IN-2

验证数据展示

  • CAS No.: 1919853-46-5

    PTP1B-IN-2
    CAS#: 1919853-46-5

产品信息

CAS号 1919853-46-5
分子式 C34H36N2O9S2
主要靶点 Phosphatase
主要通路 代谢
分子量 680.79
纯度 99.58%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 inhibit|Inhibitor|Phosphatase|PTP1B|PTP1B IN 2|PTP1BIN2|PTP-1B-IN-2|PTP1B-IN-2

靶点活性

PTP1B:50 nM

体外活性

PTP1B-IN-2深入活性位点口袋，与催化位点的关键残基形成多个氢键和疏水作用。在15μM及30μM浓度下，PTP1B-IN-2显著增强胰岛素介导的IRβ磷酸化。

溶解度

DMSO:45 mg/mL (66.1 mM)

参考文献

1.Liu P, et al. Discovery of novel, high potent, ABC type PTP1B inhibitors with TCPTP selectivity and cellular activity. Eur J Med Chem. 2016 Aug 8;118:27-33.
2.Wu R, Wang C, Li Z, et al. SOX2 promotes resistance of melanoma with PD-L1 high expression to T-cell-mediated cytotoxicity that can be reversed by SAHA[J]. Journal for immunotherapy of cancer. 2020, 8(2).

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2