验证数据展示
产品信息
84300-1-PBS targets PTBP2 in Indirect ELISA applications and shows reactivity with human, mouse samples.
| 经测试应用 | Indirect ELISA Application Description |
| 经测试反应性 | human, mouse |
| 免疫原 | Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | polypyrimidine tract binding protein 2 |
| 别名 | PTB, Polypyrimidine tract-binding protein 2, Neurally-enriched homolog of PTB, Neural polypyrimidine tract-binding protein, brPTB |
| 计算分子量 | 57 kDa |
| 观测分子量 | 57-60 kDa |
| GenBank蛋白编号 | NM_021190 |
| 基因名称 | PTBP2 |
| Gene ID (NCBI) | 58155 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purfication |
| UNIPROT ID | Q9UKA9 |
| 储存缓冲液 | PBS only , pH 7.3 |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
PTBP2, also named as NPTB, PTB and PTBLP, is a RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. It may antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. Beside its function in pre-mRNA splicing, PTBP2 plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA. (PMID:11003644) . Protein may exist in a dimeric form with a MW of 110-120 kDa (PMID: 20064465). This antibody is specific to PTBP2.