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验证数据展示

  • WB analysis using 87496-1-RR (same clone as 87496-1-PBS)

    WB analysis using 87496-1-RR (same clone as 87496-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 87496-1-RR (PPIL2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 87496-1-PBS in a different storage buffer formulation.

  • WB analysis of HEK-293 using 87496-1-RR (same clone as 87496-1-PBS)

    WB analysis of HEK-293 using 87496-1-RR (same clone as 87496-1-PBS)

    HEK-293 cells were subjected to SDS PAGE followed by western blot with 87496-1-RR (PPIL2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 87496-1-PBS in a different storage buffer formulation.

PPIL2 Recombinant monoclonal antibody, PBS Only

PPIL2 Uni-rAb® Recombinant Antibody for WB, Indirect ELISA
Cat No. 87496-1-PBS

产品说明书

CloneNo. 252848F8

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, Indirect ELISA

别名

Cyclophilin-60, Cyclophilin-like protein Cyp-60, Cyp-60, EC:2.3.2.27, hCyP-60

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

87496-1-PBS targets PPIL2 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Eg6018

Product name: Recombinant human PPIL2 protein

Source: mammalian cells-derived, V37

Tag: C-rFc

Domain: 280-457 aa of NM_148176.2

Sequence: GYVRLHTNKGDLNLELHCDLTPKTCENFIRLCKKHYYDGTIFHRSIRNFVIQGGDPTGTGTGGESYWGKPFKDEFRPNLSHTGRGILSMANSGPNSNRSQFFITFRSCAYLDKKHTIFGRVVGGFDVLTAMENVESDPKTDRPKEEIRIDATTVFVDPYEEADAQIAQERKTQLKVAP

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 peptidylprolyl isomerase (cyclophilin)-like 2
别名 Cyclophilin-60, Cyclophilin-like protein Cyp-60, Cyp-60, EC:2.3.2.27, hCyP-60
计算分子量59 kDa
GenBank蛋白编号NM_148176.2
基因名称 PPIL2
Gene ID (NCBI) 23759
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDQ13356-2
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Peptidylprolyl isomerase (cyclophilin)-like 2 (PPIL2), also known as Cyclophilin-like protein Cyp-60, is a U-box-type E3 ubiquitin ligase belonging to the cyclophilin family. PPIL2 is also a target of the JAK2/STAT5 pathway and upregulated in patients with MPNs (PMID: 36092721, 25992900). PPIL2 is a large ~60 kDa (520 amino acids) protein that has a central cyclophilin-like domain and also has an N-terminal U-box domain that exhibits E3 ligase activity. Western detected PPIL2 at an apparent molecular mass of 60~70 kDa (PMID: 40338661, 29352246).

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