验证数据展示
产品信息
15646-1-PBS targets POLD1 in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human samples.
经测试应用 | WB, IHC, IP, Indirect ELISA Application Description |
经测试反应性 | human |
免疫原 | POLD1 fusion protein Ag8178 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Polyclonal |
产品类型 | Antibody |
全称 | polymerase (DNA directed), delta 1, catalytic subunit 125kDa |
别名 | |
计算分子量 | 1107 aa, 124 kDa |
观测分子量 | 124 kDa |
GenBank蛋白编号 | BC008800 |
基因名称 | POLD1 |
Gene ID (NCBI) | 5424 |
RRID | AB_2252572 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Antigen affinity purification |
UNIPROT ID | P28340 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
POLD1, also known as DNA polymerase subunit delta p125, is 1107 amino acid protein, which belongs to the DNA polymerase type-B family. POLD1 colocalizes with PCNA and POLD3 at S phase replication sites (PubMed:11595739). As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. A previous study demonstrated that overexpression of POLD1 is associated with an increased risk of breast cancer. (PMID: 30344713 )