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PFK-158

PFK158 是一种选择性的PFKFB3抑制剂，IC50值为 137 nM。它可减少癌细胞中葡萄糖的摄取，ATP 的产生，乳酸的释放，并诱导细胞凋亡和自噬。它还可以增强 Colistin 对细菌的抵抗力，具有广泛的抗肿瘤活性。

CAS号

1462249-75-7

分子式

C18H11F3N2O

主要靶点

Apoptosis|Autophagy|Glucokinase

仅限科研使用

Cat No : CM05840

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Synonyms

验证数据展示

  • CAS No.: 1462249-75-7

    PFK-158
    CAS#: 1462249-75-7

产品信息

PFK-158 is an effective and specific inhibitor PFKFB3.

CAS号 1462249-75-7
分子式 C18H11F3N2O
主要靶点 Apoptosis|Autophagy|Glucokinase
主要通路 代谢|自噬|凋亡
分子量 328.29
纯度 97.55%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

PFKFB3:137 nM (IC50 )

溶解度

DMSO:>30 mg/mL

参考文献

1.Rebecca Redman, et al. Y Res August 1, 2015 75; CT206.
2.Zhang Y, Wang X, Li X, et al. Synergistic effect of colistin combined with PFK-158 against colistin-resistant Enterobacteriaceae[J]. Antimicrobial agents and chemotherapy. 2019, 63(7): e00271-19.

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