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PFK-015

CAS号

4382-63-2

分子式

C17H12N2O

主要靶点

Glucokinase|Autophagy

仅限科研使用

Cat No : CM05839

Print datasheet

Synonyms

lung cancer|Inhibitor|PFKFB3|PFK 015|PFK 15|PFK015|PFK-015|PFK15|PFK-15|stomach cancer|3PO|colon cancer|Autophagy|cancers|esophageal squamous cell carcinoma (ESCC)|inhibit

验证数据展示

  • CAS No.: 4382-63-2

    PFK-015
    CAS#: 4382-63-2

产品信息

CAS号 4382-63-2
分子式 C17H12N2O
主要靶点 Glucokinase|Autophagy
主要通路 代谢|自噬
分子量 260.29
纯度 99.7%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 lung cancer|Inhibitor|PFKFB3|PFK 015|PFK 15|PFK015|PFK-015|PFK15|PFK-15|stomach cancer|3PO|colon cancer|Autophagy|cancers|esophageal squamous cell carcinoma (ESCC)|inhibit

靶点活性

PFKFB3:110 nM|PFKFB3:20 nM

体内活性

在Jurkat T-细胞白血病细胞和H522肺腺癌细胞中,PFK-015可使F26BP、葡萄糖摄取及细胞内腺嘌呤核苷三磷酸水平降低。PFK-015还对一系列癌细胞的生长具有明显的抑制作用。

体外活性

PFK-015（25 mg/kg,i.p.）对同源小鼠体内LLC肿瘤的生长、转移扩散及葡萄糖代谢具有抑制作用.在三个人异种移植的无胸腺癌症小鼠模型中,PFK-015与公认化疗药物的抗癌效果相似.PFK-015有适当的体内药代动力学性质.

溶解度

DMSO:3 mg/mL (11.53 mM)

细胞实验

Viability is determined using trypan blue exclusion. Cells were incubated in 20% trypan blue for 5 minutes. Cells excluding trypan blue are counted using a standard hemocytometer to determine the total number of viable cells. Experiments are conducted in triplicate. (Only for Reference)

参考文献

1.Clem BF, et al. Mol Cancer Ther. 2013, 12(8), 1461-1470.
2.Zhang Y, Wang X, Li X, et al. Synergistic effect of colistin combined with PFK-158 against colistin-resistant Enterobacteriaceae[J]. Antimicrobial agents and chemotherapy. 2019, 63(7): e00271-19.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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C1   V1   C2   V2