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Ropsacitinib

Ropsacitinib (PF-06826647) 是一种选择性TYK2抑制剂。Ropsacitinib 与Tyk2催化活性JH1结构域结合(IC50:17nM)。

CAS号

2127109-84-4

分子式

C20H17N9

主要靶点

Tyrosine Kinases

仅限科研使用

Cat No : CM04910

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Synonyms

Tyk2-IN-8|PF-06826647

验证数据展示

  • CAS No.: 2127109-84-4

    Ropsacitinib
    CAS#: 2127109-84-4

产品信息

Ropsacitinib is a selective TYK2 inhibitor, which binds to TYK2 catalytically active JH1 domain (IC50: 17 nM).

CAS号 2127109-84-4
分子式 C20H17N9
主要靶点 Tyrosine Kinases
主要通路 蛋白酪氨酸激酶
分子量 383.41
纯度 99.85%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Tyk2-IN-8|PF-06826647

靶点活性

TYK2 JH1:17 nM

体外活性

Ropsacitinib suppresses JAK1 (IC50=74 nM) and JAK2 (IC50=383 nM) [1].

溶解度

DMSO:10 mg/mL (26.08 mM)

参考文献

1.Wrobleski ST, et al. Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165. J Med Chem. 2019 Jul 18.

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