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PF-06446846

CAS号

1632250-49-7

分子式

C22H20ClN7O

主要靶点

Others

仅限科研使用

Cat No : CM05763

Print datasheet

Synonyms

Huh7|80S ribosome|Threonine proteases|Ser/Thr Protease|Serine endopeptidases|Serine proteases|Selective|inhibit|Inhibitor|PCSK9|Rat bone marrow|PF 06446846|PF06446846|PF-06446846

验证数据展示

  • CAS No.: 1632250-49-7

    PF-06446846
    CAS#: 1632250-49-7

产品信息

CAS号 1632250-49-7
分子式 C22H20ClN7O
主要靶点 Others
主要通路 其他
分子量 433.89
纯度 99.4%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Huh7|80S ribosome|Threonine proteases|Ser/Thr Protease|Serine endopeptidases|Serine proteases|Selective|inhibit|Inhibitor|PCSK9|Rat bone marrow|PF 06446846|PF06446846|PF-06446846

体内活性

PF-06446846 在口服给药后能够降低大鼠的血浆PCSK9及总胆固醇水平。该化合物对于抑制PCSK9的翻译具有高度的选择性。PF-06446846所采用的作用机理揭示了人类核糖体之前未被预料到的可调控性，这种性质允许小分子特异性地阻断个别转录本的翻译。

溶解度

DMSO:4.34 mg/mL (10 mM)

参考文献

1.Lintner N G , Mcclure K F , Donna P , et al. Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain[J]. PLoS Biology, 2017, 15(3):e2001882-.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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C1   V1   C2   V2