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PD 90780

CAS号

77422-99-2

分子式

C19H14N4O4

主要靶点

Others

仅限科研使用

Cat No : CM10549

Print datasheet

Synonyms

PD 90780|PD90780|PD-90780

验证数据展示

  • CAS No.: 77422-99-2

    PD 90780
    CAS#: 77422-99-2

产品信息

CAS号 77422-99-2
分子式 C19H14N4O4
主要靶点 Others
主要通路 其他
分子量 362.34
纯度 98.75%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 PD 90780|PD90780|PD-90780

靶点活性

NGF (PC12 nnr5 cells):1.8 μM |NGF (PC12 cells):23.1 μM

体外活性

PD 90780（0.1-100 μM；2小时）影响125I-BDNF与截短型p75NTR的结合。PD 90780（100 μM；2小时）抑制125I-NGF与p75NTR的交联。PD 90780（0-300 μM；2小时）随着剂量增至300 μM，降低因NGF结合而导致的TrkA磷酸化。PD 90780（0.1-100 μM；2小时）抑制NGF与p75NTR的相互作用，其中在PC12细胞和PC12nnr5细胞中的IC50值分别为23.1 μM和1.8 μM[1]。

溶解度

DMSO:28.8 mg/mL (79.5 mM)

参考文献

1.Colquhoun A , et al. Differential activity of the nerve growth factor (NGF) antagonist PD90780 [7-(benzolylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid] suggests altered NGF-p75NTR interactions in the presence of TrkA. J Pharmacol Exp Ther. 2004 Aug;310(2):505-11.

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