验证数据展示
Planning an IHC experiment? We recommend our IHCeasy PARK2 Ready-To-Use IHC Kit. PARK2 primary antibody included.
For other applications, we recommend the unconjugated version of this antibody, 66674-1-Ig
产品信息
CL594-66674 targets PARK2/Parkin in applications and shows reactivity with Human, Mouse samples.
| 经测试应用 | Application Description |
| 经测试反应性 | Human, Mouse |
| 免疫原 | PARK2/Parkin fusion protein Ag5179 种属同源性预测 |
| 宿主/亚型 | Mouse / IgG2b |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | Parkinson disease (autosomal recessive, juvenile) 2, parkin |
| 别名 | AR JP, LPRS2, PARK2, Parkinson disease protein 2, PDJ, PRKN |
| 计算分子量 | 52 kDa |
| 观测分子量 | 42-52 kDa |
| GenBank蛋白编号 | BC022014 |
| 基因名称 | Parkin |
| Gene ID (NCBI) | 5071 |
| 偶联类型 | CoraLite® Plus 594 Fluorescent Dye |
| 最大激发/发射波长 | 588 nm / 604 nm |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | O60260 |
| 储存缓冲液 | PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA , pH 7.3 |
| 储存条件 | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Parkin, a RING-type E3 ubiquitin-protein ligase, is involved in the ubiquitination pathway and contributes to protection from neurotoxicity induced by unfolded protein stresses. Its ubiquitin-protein ligase activity promotes the degradation of a viariety of proteins including itself. Mutations in Parkin are implicated in the pathogenesis of autosomal recessive familial Parkinson's disease. It has 8 isoforms produced by alternative splicing.