验证数据展示
Planning an IHC experiment? We recommend our IHCeasy SERPINE1 Ready-To-Use IHC Kit. SERPINE1 primary antibody included.
发表文章中的应用
IHC | See 1 publications below |
产品信息
25522-1-AP targets PAI-1 in IHC, ELISA applications and shows reactivity with human, mouse samples.
经测试应用 | ELISA Application Description |
文献引用应用 | IHC |
经测试反应性 | human, mouse |
文献引用反应性 | human |
免疫原 | PAI-1 fusion protein Ag22411 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Polyclonal |
产品类型 | Antibody |
全称 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
别名 | SERPINE1, PAI-1, SERPINE1, Plasminogen activator inhibitor 1, PAI1, PAI 1 |
计算分子量 | 402 aa, 45 kDa |
GenBank蛋白编号 | BC010860 |
基因名称 | PAI-1 |
Gene ID (NCBI) | 5054 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Antigen affinity purification |
UNIPROT ID | P05121 |
储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
SERPINE1, also named as Plasminogen activator inhibitor type 1 (PAI-1), is a member of the serine protease inhibitor (SERPIN) superfamily. PAI-1 is the principal inhibitor of tissue plasminogen activator (tPA) and uPA, and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia.