• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

ONO-7300243

CAS号

638132-34-0

分子式

C28H31NO5

主要靶点

LPA Receptor|LPL Receptor

仅限科研使用

Cat No : CM04985

Print datasheet

Synonyms

Inhibitor|Lysophospholipid Receptor|LPA Receptor|LPL|LPA1|LPAReceptor|LPLReceptor|LPL Receptor|ONO 7300243|ONO7300243|ONO-7300243|inhibit

验证数据展示

  • CAS No.: 638132-34-0

    ONO-7300243
    CAS#: 638132-34-0

产品信息

CAS号 638132-34-0
分子式 C28H31NO5
主要靶点 LPA Receptor|LPL Receptor
主要通路 G 蛋白偶联受体|G 蛋白偶联受体
分子量 461.55
纯度 99.66%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Inhibitor|Lysophospholipid Receptor|LPA Receptor|LPL|LPA1|LPAReceptor|LPLReceptor|LPL Receptor|ONO 7300243|ONO7300243|ONO-7300243|inhibit

靶点活性

LPA1:0.19-0.13 μM (IC50)

体内活性

通过口服给药ONO-7300243 来确定其对大鼠IUP的影响。ONO-7300243 以剂量依赖性方式抑制了LPA诱导的IUP增加（ID50 = 11.6 mg/kg p.o.），直到给药后1小时。在10和30mg/kg剂量下观察到显着效果（p < 0.05 vs vehicle）. ONO-7300243 （30 mg/kg, p.o.）在没有LPA刺激的情况下，与vehicle比较，显着降低了清醒大鼠的IUP，同时不影响平均血压（MBP）[1]。

溶解度

DMSO:100 mg/mL (216.66 mM)

参考文献

1.Terakado M , Suzuki H , Hashimura K , et al. Discovery of ONO-7300243 from a novel class of Lysophosphatidic Acid Receptor 1 antagonists: From hit to lead.[J]. ACS Medicinal Chemistry Letters, 2016:acsmedchemlett.6b00225.
2.Terakado M , Suzuki H , Hashimura K , et al. Discovery of a Slow Tight Binding LPA1 Antagonist (ONO-0300302) for the Treatment of Benign Prostatic Hyperplasia[J]. ACS Medicinal Chemistry Letters, 2017:acsmedchemlett.7b00383.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2