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OICR-9429

CAS号

1801787-56-3

分子式

C29H32F3N5O3

主要靶点

JAK|Histone Methyltransferase

仅限科研使用

Cat No : CM04577

Print datasheet

Synonyms

leukaemia|MLL|Inhibitor|OICR9429|OICR-9429|OICR 9429|pancreatic|prostate cance|WD repeat domain 5 (WDR5)|WDR5|inhibit|H3K4|HistoneMethyltransferase|Histone Methyltransferase|Apoptosis|bladder cancer (BCa)|colon

验证数据展示

  • CAS No.: 1801787-56-3

    OICR-9429
    CAS#: 1801787-56-3

产品信息

CAS号 1801787-56-3
分子式 C29H32F3N5O3
主要靶点 JAK|Histone Methyltransferase
主要通路 表观遗传|蛋白酪氨酸激酶|干细胞|血管生成|JAK/STAT 信号通路|表观遗传
分子量 555.59
纯度 99.93%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 leukaemia|MLL|Inhibitor|OICR9429|OICR-9429|OICR 9429|pancreatic|prostate cance|WD repeat domain 5 (WDR5)|WDR5|inhibit|H3K4|HistoneMethyltransferase|Histone Methyltransferase|Apoptosis|bladder cancer (BCa)|colon

靶点活性

WDR5:93 nM(Kd)

体外活性

OICR-9429以高亲和性结合WDR5（Kd=93±28 nM），并竞争性地干扰其与MLL中高亲和性Wdr5-interacting (WIN) 肽的相互作用（Kdisp=64±4 nM）[1]。

溶解度

DMSO:50 mg/mL (89.99 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:12 mg/mL (21.6 mM)

细胞实验

20,000 viable, actively proliferating primary human AML cells per well were seeded in 96-well plates in triplicates and treated with 0.05% DMSO or OICR-9429. Cell viability was measured using the Cell Titer-Glo luminescent cell viability assay on a VICTOR X4 luminometer after 72 h.(Only for Reference)

参考文献

1.Grebien F, et al. Nat Chem Biol. 2015, 11(8):571-8.

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