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O-304

O-304 是 AMP 活化蛋白激酶 (AMPK) 的泛激活剂，可通过抑制 pAMPK 的去磷酸化来增加 AMPK 活性，可用于 2 型糖尿病和相关心血管并发症的研究。

CAS号

1261289-04-6

分子式

C16H11Cl2N3O2S

主要靶点

AMPK

仅限科研使用

Cat No : CM02679

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Synonyms

验证数据展示

  • CAS No.: 1261289-04-6

    O-304
    CAS#: 1261289-04-6

产品信息

O-304 is a pan-activator of AMP-activated protein kinase (AMPK).

CAS号 1261289-04-6
分子式 C16H11Cl2N3O2S
主要靶点 AMPK
主要通路 PI3K/Akt/mTOR信号通路|表观遗传
分子量 380.25
纯度 ， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

体内活性

In vivo, O-304 (100 mg/kg) prevents high-fat diet-induced increases in fasted glucose and plasma insulin levels and development of insulin resistance, as well as increases calf muscle pAMPK levels in mice.

溶解度

DMSO:30 mg/mL (78.90 mM)

参考文献

1.Steneberg, Pär, Lindahl E , Dahl U , et al. PAN-AMPK activator O304 improves glucose homeostasis and microvascular perfusion in mice and type 2 diabetes patients[J]. JCI Insight, 2018, 3(12).

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