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Nizatidine

CAS号

76963-41-2

分子式

C12H21N5O2S2

主要靶点

AChE|Histamine Receptor

仅限科研使用

Cat No : CM04503

Print datasheet

Synonyms

inhibit|HistamineReceptor|Histamine Receptor|hcc|H2 receptor|gastroesophageal reflux disease|GERD|erosive esophagitis|Acinon|acid|AChE|Axid|cancer|尼扎替丁|stomach|Zanizal|Inhibitor|intestines ulcers|Nizatidine

验证数据展示

  • CAS No.: 76963-41-2

    Nizatidine
    CAS#: 76963-41-2

产品信息

CAS号 76963-41-2
分子式 C12H21N5O2S2
主要靶点 AChE|Histamine Receptor
主要通路 神经科学|G 蛋白偶联受体|免疫与炎症|神经科学
分子量 331.46
纯度 99.87%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 inhibit|HistamineReceptor|Histamine Receptor|hcc|H2 receptor|gastroesophageal reflux disease|GERD|erosive esophagitis|Acinon|acid|AChE|Axid|cancer|尼扎替丁|stomach|Zanizal|Inhibitor|intestines ulcers|Nizatidine

靶点活性

AChE:6.7 μM|H2 receptor:0.9 nM

体内活性

Nizatidine是可逆的,非竞争性的乙酰胆碱酯酶抑制剂（IC50=6.7 μM,Ki=7.4 μM）。Nizatidine是具有选择性的组胺H2受体拮抗剂,能够有效抑制胃酸分泌（IC50=0.9 nM）。

体外活性

在大鼠中（EC50=1.383 μMol/ kg）,Nizatidine给药后一小时对胃酸表现出最大的抑制作用.静脉内给药Nizatidine（0.3-3 mg / kg）能够增加胃肠运动,同时抑制胃酸分泌,对于大鼠（ED50=2.94 mg / kg和ED90=19.6 mg / kg）.

溶解度

H2O:26 mg/mL (78.4 mM);DMSO:60 mg/mL (181.02 mM);Ethanol:15 mg/mL (45.3 mM)

参考文献

1.Lin TM, et al. J Pharmacol Exp Ther, 1986, 239(2), 406-410.
2.Ueki S, et al. J Pharmacol Exp Ther, 1993, 264(1), 152-157.

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