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Nitrofurantoin

Nitrofurantoin (Furadantine) 是一种具有口服活性的广谱内酰胺酶抗菌剂。它是一种抗生素，可研究尿路感染。

CAS号

67-20-9

分子式

C8H6N4O5

主要靶点

Antibacterial|Antibiotic

仅限科研使用

Cat No : CM00402

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Synonyms

Furadantine|呋喃妥因|Macrodantin|Furadonine

验证数据展示

  • CAS No.: 67-20-9

    Nitrofurantoin
    CAS#: 67-20-9

产品信息

Nitrofurantoin, an antibiotic, inhibits bacterial DNA, RNA, and cell wall protein synthesis. Activated by bacterial flavoproteins to intermediates that inactivate bacterial ribosomal proteins, Nitrofurantoin is used prophylactically as a urinary anti-infective agent against most gram-positive and gram-negative organisms and for long-term suppression of infections.

CAS号 67-20-9
分子式 C8H6N4O5
主要靶点 Antibacterial|Antibiotic
主要通路 微生物学
分子量 238.16
纯度 99.94%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Furadantine|呋喃妥因|Macrodantin|Furadonine

体内活性

In vivo, nitrofurantoin (25-100 mg/kg, i.m.) reduces E. coli replication and abscess formation in the renal medulla of infected rats in a dose-dependent manner. It prevents kidney and bladder infection in rats following bladder inoculation with clinical isolates of P. mirabilis. Nitrofurantoin also prevents alkalization of urine as well as calculi and abscess formation in a rat model of P. vulgaris urinary tract infection.

溶解度

DMSO:40 mg/mL,H2O:Insoluble,Ethanol:10 mg/mL

细胞实验

HeLa cells are grown and infected with T. gondii for 24 hr in a 96-well microplate, and then treated with drugs. After 24 hr, 20 μl of MTS solution is added directly into culture wells, followed by incubating for 1.5 hr at 37?C and measuring the absorbance at 490 nm in a microplate reader. (Only for Reference)

参考文献

1.Yeo SJ, et al. In Vitro and in Vivo Effects of Nitrofurantoin on Experimental Toxoplasmosis. Korean J Parasitol. 2016 Apr;54(2):155-61.
2.Martin WJ, et al. Am Rev Respir Dis. 1983, 127(4):482-486.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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C1   V1   C2   V2