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Nitrofurantoin

CAS号

67-20-9

分子式

C8H6N4O5

主要靶点

Antibacterial|Antibiotic

仅限科研使用

Cat No : CM00402

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Synonyms

E. coli|cystitis|Furadantine|Furadonine|infection|Antibiotic|Antibacterial|antimicrobial|Bacterial|呋喃妥因|UTI|urinary tract|Macrodantin|inhibit|Inhibitor|kidney|Nitrofurantoin

验证数据展示

  • CAS No.: 67-20-9

    Nitrofurantoin
    CAS#: 67-20-9

产品信息

CAS号 67-20-9
分子式 C8H6N4O5
主要靶点 Antibacterial|Antibiotic
主要通路 微生物学|微生物学
分子量 238.16
纯度 99.94%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 E. coli|cystitis|Furadantine|Furadonine|infection|Antibiotic|Antibacterial|antimicrobial|Bacterial|呋喃妥因|UTI|urinary tract|Macrodantin|inhibit|Inhibitor|kidney|Nitrofurantoin

体内活性

在体内，Nitrofurantoin （25-100 mg/kg，i.m.）以剂量依赖性方式减少了感染大鼠肾髓中的大肠杆菌复制和脓肿形成。它还能够预防大鼠在膀胱接种P. mirabilis临床分离株后的肾脏和膀胱感染。此外，Nitrofurantoin 亦在P. vulgaris尿道感染的大鼠模型中阻止尿液碱化和结石及脓肿形成。

溶解度

H2O:Insoluble;Ethanol:10 mg/mL;DMSO:50 mg/mL (209.94 mM)

细胞实验

HeLa cells are grown and infected with T. gondii for 24 hr in a 96-well microplate, and then treated with drugs. After 24 hr, 20 μl of MTS solution is added directly into culture wells, followed by incubating for 1.5 hr at 37?C and measuring the absorbance at 490 nm in a microplate reader. (Only for Reference)

参考文献

1.Yeo SJ, et al. In Vitro and in Vivo Effects of Nitrofurantoin on Experimental Toxoplasmosis. Korean J Parasitol. 2016 Apr;54(2):155-61.
2.Martin WJ, et al. Am Rev Respir Dis. 1983, 127(4):482-486.

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