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Nilotinib monohydrochloride monohydrate

CAS号

923288-90-8

分子式

C28H22F3N7O.HCl.H2O

主要靶点

Bcr-Abl|Autophagy

仅限科研使用

Cat No : CM03138

Print datasheet

Synonyms

尼洛替尼盐酸盐一水合物|尼罗替尼中间体|tyrosine kinase|Inhibitor|Nilotinib|Nilotinib (monohydrochloride monohydrate)|Nilotinib monohydrochloride|Nilotinib monohydrochloride Monohydrate|Nilotinib monohydrochloride monohydrate|inhibit|BcrAbl|Bcr-Abl|Autophagy|antitumor|AMN107|AMN 107|AMN-107|AMN107 (monohydrochloride monohydrate)|AMN107 monohydrochloride

验证数据展示

  • CAS No.: 923288-90-8

    Nilotinib monohydrochloride monohydrate
    CAS#: 923288-90-8

产品信息

CAS号 923288-90-8
分子式 C28H22F3N7O.HCl.H2O
主要靶点 Bcr-Abl|Autophagy
主要通路 血管生成|细胞骨架|蛋白酪氨酸激酶|自噬
分子量 583.99
纯度 99.93%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 尼洛替尼盐酸盐一水合物|尼罗替尼中间体|tyrosine kinase|Inhibitor|Nilotinib|Nilotinib (monohydrochloride monohydrate)|Nilotinib monohydrochloride|Nilotinib monohydrochloride Monohydrate|Nilotinib monohydrochloride monohydrate|inhibit|BcrAbl|Bcr-Abl|Autophagy|antitumor|AMN107|AMN 107|AMN-107|AMN107 (monohydrochloride monohydrate)|AMN107 monohydrochloride

体内活性

在吲哚美辛诱导的大鼠肠炎模型中，Nilotinib 对宏观和显微病理评分具有积极效果，确保了显著的黏膜愈合。Nilotinib 降低了PDGFR α和β水平，并提高了结肠凋亡评分[2]。

溶解度

DMSO:45 mg/mL (77.06 mM)

参考文献

1.Sako H , Fukuda K , Saikawa Y , et al. Antitumor Effect of the Tyrosine Kinase Inhibitor Nilotinib on Gastrointestinal Stromal Tumor (GIST) and Imatinib-Resistant GIST Cells[J]. PLOS ONE, 2014, 9(9):e107613.
2.Gozde Dervis Hakim Mujde Soyturk Mehtat Unlu Pinar Ataca Meral Karaman Ozgul Sagol Elif Borekci Osman Yilmaz. Mucosal healing effect of nilotinib in indomethacin-induced enterocolitis:A rat model[J]. 2015.

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