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Nilotinib monohydrochloride monohydrate

Nilotinib monohydrochloride monohydrate (Nilotinib (monohydrochloride monohydrate)) 是酪氨酸酶抑制剂，有效抑制 BCR-ABL 及其突变体。

CAS号

923288-90-8

分子式

C28H22F3N7O.HCl.H2O

主要靶点

Bcr-Abl|Autophagy

仅限科研使用

Cat No : CM03138

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Synonyms

AMN107 (monohydrochloride monohydrate)|尼洛替尼盐酸盐一水合物|Nilotinib (monohydrochloride monohydrate)|尼罗替尼中间体

验证数据展示

  • CAS No.: 923288-90-8

    Nilotinib monohydrochloride monohydrate
    CAS#: 923288-90-8

产品信息

Nilotinib monohydrochloride monohydrate is significantly potent BCR-ABL against, is a second generation tyrosine kinase inhibitor (TKI), and is active against many BCR-ABL mutants.

CAS号 923288-90-8
分子式 C28H22F3N7O.HCl.H2O
主要靶点 Bcr-Abl|Autophagy
主要通路 血管生成|蛋白酪氨酸激酶|细胞骨架|自噬
分子量 583.99
纯度 99.70%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 AMN107 (monohydrochloride monohydrate)|尼洛替尼盐酸盐一水合物|Nilotinib (monohydrochloride monohydrate)|尼罗替尼中间体

体内活性

In the indomethacin-induced enterocolitis rat model, nilotinib has a positive effect on the macroscopic and microscopic pathologic scores, ensuring considerable mucosal healing.?Nilotinib decreases PDGFR α and β levels and increases the colonic apoptotic scores[2].

溶解度

DMSO:33 mg/mL (56.51 mM)

参考文献

1.Sako H , Fukuda K , Saikawa Y , et al. Antitumor Effect of the Tyrosine Kinase Inhibitor Nilotinib on Gastrointestinal Stromal Tumor (GIST) and Imatinib-Resistant GIST Cells[J]. PLOS ONE, 2014, 9(9):e107613.
2.Gozde Dervis Hakim Mujde Soyturk Mehtat Unlu Pinar Ataca Meral Karaman Ozgul Sagol Elif Borekci Osman Yilmaz. Mucosal healing effect of nilotinib in indomethacin-induced enterocolitis:A rat model[J]. 2015.

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