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Necrosulfonamide

(E/Z)-Necrosulfonamide 是一种新型的 MLKL 抑制剂。

CAS号

432531-71-0

分子式

C18H15N5O6S2

主要靶点

MLK

仅限科研使用

Cat No : CM05180

Print datasheet

Synonyms

N-[4-[[(3-甲氧基吡嗪基)氨基]磺酰基]苯基]-3-(5-硝基-2-噻吩基)-2-丙烯酰胺

验证数据展示

  • CAS No.: 432531-71-0

    Necrosulfonamide
    CAS#: 432531-71-0

产品信息

Necrosulfonamide is a novel inhibitor of MLKL.

CAS号 432531-71-0
分子式 C18H15N5O6S2
主要靶点 MLK
主要通路 MAPK信号通路
分子量 461.47
纯度 98.00%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 N-[4-[[(3-甲氧基吡嗪基)氨基]磺酰基]苯基]-3-(5-硝基-2-噻吩基)-2-丙烯酰胺

体内活性

Necrosulfonamide attenuates the spinal cord injury via necroptosis inhibition[1]

溶解度

DMSO:25 mg/mL (54.17 mM)

动物实验

Pathologic condition was detected using hematoxylin-eosin staining on injured spinal cord and other major organs. Necroptosis-related factors-RIP1, RIP3, and MLKL-were detected using Western blot. Detections on mitochondrial functions such as adenosine triphosphate generation and activities of superoxide dismutase and caspase-3 were also performed. Finally, ethologic performance was detected using a 21-point open-field locomotion test[1].

参考文献

1.Wang Y , Wang J , Wang H , et al. Necrosulfonamide Attenuates the Spinal Cord Injury Via Necroptosis Inhibition[J]. World Neurosurgery, 2018:S1878875018306569.
2.Menacher G , Balszuweit F , Lang S , et al. Necrosulfonamide – Unexpected effect in the course of a sulfur mustard intoxication[J]. Chemico-Biological Interactions, 2018.
3.Sun Y, He L, Wang T, et al. Activation of p62-Keap1-Nrf2 Pathway Protects 6-Hydroxydopamine-Induced Ferroptosis in Dopaminergic Cells[J]. Molecular Neurobiology. 2020, 57(11): 4628-4641.

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