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Nafcillin sodium monohydrate

Nafcillin sodium monohydrate (CL 8491) 是一种抗生素，是可逆的β-lactamase 抑制剂。它用于治疗由耐青霉素的葡萄球菌菌株引起的感染。

CAS号

7177-50-6

分子式

C21H21N2O5SNa·H2O

主要靶点

Antibacterial|Antibiotic

仅限科研使用

Cat No : CM02852

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Synonyms

nafcillin sodium|萘夫西林钠|CL 8491

验证数据展示

  • CAS No.: 7177-50-6

    Nafcillin sodium monohydrate
    CAS#: 7177-50-6

产品信息

Nafcillin sodium monohydrate (CL 8491) is the sodium salt form of nafcillin, a semi-synthetic naphthalene, penicillin-related Nafcillin inhibits bacterial wall synthesis by a mechanism of action similar to penicillin. Penicillinase-resistant Nafcillin is used to treat infections caused by penicillin-resistant strains of Staphylococci.

CAS号 7177-50-6
分子式 C21H21N2O5SNa·H2O
主要靶点 Antibacterial|Antibiotic
主要通路 微生物学
分子量 454.47
纯度 98.00%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 nafcillin sodium|萘夫西林钠|CL 8491

靶点活性

β-lactamase:33 mM(Kd)

体内活性

通过Ser-70与β-内酰胺酶形成共价的酰基酶中间体,Nafcillin sodium可使β-内酰胺酶灭活。Nafcillin（>80 mM,<200s）完全抑制β-内酰胺酶活性。去除Nafcillin后,受抑制的酶可重新被完全激活,速率常数为2×10-3/s (25 ℃)。

溶解度

DMSO:84 mg/mL (184.8 mM),H2O:83 mg/mL (182.6 mM),Ethanol:16 mg/mL (35.2 mM)

参考文献

1.Tan AK, et al. Biochem J, 1992, 281 ( Pt 1), 191-196.
2.Schwichtenberg AH. JAMA, 1965, 191:930-931.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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C1   V1   C2   V2