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NRC-2694

NRC-2694 是表皮生长因子受体的有效拮抗剂，具抗增殖、有抗癌的活性。

CAS号

936446-61-6

分子式

C24H26N4O3

主要靶点

EGFR

仅限科研使用

Cat No : CM03918

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Synonyms

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  • CAS No.: 936446-61-6

    NRC-2694
    CAS#: 936446-61-6

产品信息

NRC-2694 is an antagonist of the epidermal growth factor receptor (EGFR). It has anti-cancer and anti-proliferative properties.

CAS号 936446-61-6
分子式 C24H26N4O3
主要靶点 EGFR
主要通路 蛋白酪氨酸激酶|JAK/STAT信号通路|血管生成
分子量 418.49
纯度 99.38%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

体内活性

NRC-2694 (10 mg/kg) regresses the tumor in mice. The maximum tolerated dose of NRC-2694 in male and female mice is 2000 mg/kg (p.o.), in toxicity studies .

体外活性

NRC-2694 (80 ng) induce comparable inhibition of EGFR expression.

溶解度

DMSO:250 mg/mL (597.39 mM),Sonification is recommended.

参考文献

1.Ramanadham Jyothi Prasad, et al. 6-7,dialkoxy quinazoline derivatives useful for treatment of cancer related disorders. US 8143250 B2

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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=
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C1   V1   C2   V2