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NF-κB-IN-1

CAS号

1227098-15-8

分子式

C31H30O8

主要靶点

IκB/IKK|NF-κB

仅限科研使用

Cat No : CM11371

Print datasheet

Synonyms

crucumin|I kappa B kinase|inhibit|IkB|IkB/IKK|IKK|cancer|4-arylidene|1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-|A549|signaling|IκB kinase|IκB|Inhibitor|pathway|NFκB|NF-κB|NF-kB|NF-kB-IN-1|NF-kappaB-IN-1|NF κB IN 1|NFkB|NFκBIN1|NF-κB-IN-1

验证数据展示

  • CAS No.: 1227098-15-8

    NF-κB-IN-1
    CAS#: 1227098-15-8

产品信息

CAS号 1227098-15-8
分子式 C31H30O8
主要靶点 IκB/IKK|NF-κB
主要通路 NF-κB 信号通路|NF-κB 信号通路
分子量 530.57
纯度 99.03%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 crucumin|I kappa B kinase|inhibit|IkB|IkB/IKK|IKK|cancer|4-arylidene|1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-|A549|signaling|IκB kinase|IκB|Inhibitor|pathway|NFκB|NF-κB|NF-kB|NF-kB-IN-1|NF-kappaB-IN-1|NF κB IN 1|NFkB|NFκBIN1|NF-κB-IN-1

体外活性

NF-κB-IN-1 (0.5-25 μM; 预处理30分钟或4小时) 在A549细胞中强效阻断IκB磷酸化及降解。其(0.001-100 μM; 72小时) 抑制A549、H1944、H460及H157细胞生长，相应的GI50值分别为0.72、0.07、0.13、0.16 μM。NF-κB-IN-1 (0.1-0.4 μM; 9天) 抑制肺癌克隆形成活性。NF-κB-IN-1 (0.1-100 μM; 预处理30分钟) 依剂量抑制TNFα诱导的NF-κB在A549细胞中的核内转移，IC50值为1.0 μM[1]。

溶解度

DMSO:40 mg/mL (75.39 mM)

参考文献

1.Qiu X, et, al. Synthesis and identification of new 4-arylidene curcumin analogues as potential anticancer agents targeting nuclear factor-κB signaling pathway. J Med Chem. 2010 Dec 9;53(23):8260-73.

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