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验证数据展示

  • WB analysis using 28447-1-AP (same clone as 28447-1-PBS)

    WB analysis using 28447-1-AP (same clone as 28447-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 28447-1-AP (NCX1 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 28447-1-PBS in a different storage buffer formulation.

  • IHC staining of human kidney using 28447-1-AP (same clone as 28447-1-PBS)

    IHC staining of human kidney using 28447-1-AP (same clone as 28447-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 28447-1-AP (NCX1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 28447-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with SLC8A1 antibody included
  • WB analysis using 28447-1-AP (same clone as 28447-1-PBS)

    WB analysis using 28447-1-AP (same clone as 28447-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 28447-1-AP (NCX1 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 28447-1-PBS in a different storage buffer formulation.

  • IHC staining of human kidney using 28447-1-AP (same clone as 28447-1-PBS)

    IHC staining of human kidney using 28447-1-AP (same clone as 28447-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 28447-1-AP (NCX1 antibody) at dilution of 1:1600 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 28447-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with SLC8A1 antibody included

NCX1 Polyclonal antibody, PBS Only

NCX1 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 28447-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

Na(+)/Ca(2+)-exchange protein 1, SLC8A1, Solute carrier family 8 member 1

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy SLC8A1 Ready-To-Use IHC Kit. SLC8A1 primary antibody included.

产品信息

28447-1-PBS targets NCX1 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag28952

Product name: Recombinant human SLC8A1 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-59 aa of NM_021097

Sequence: MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECTGSYYCKKGV

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 solute carrier family 8 (sodium/calcium exchanger), member 1
别名 Na(+)/Ca(2+)-exchange protein 1, SLC8A1, Solute carrier family 8 member 1
计算分子量 109 kDa
观测分子量70 kDa
GenBank蛋白编号NM_021097
基因名称 NCX1
Gene ID (NCBI) 6546
RRIDAB_2918167
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP32418
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

SLC8A1, also known as NCX1, belongs to the SLC (Solute Carrier) family and the CaCA (Calcium/Cation Antiporter) superfamily. NCX1 is a bidirectional ion exchanger that can exchange sodium and calcium ions between the inside and outside of cells in a 1:3 ratio (1 Ca2+ ion and 3 Na+ ions). Under physiological conditions, NCX1 mainly transports Ca2+ from the cell interior to the exterior through the forward transport mode to maintain the low calcium level inside the cell. However, under certain special conditions, such as ischemia-reperfusion injury and stroke, the reverse transport mode of NCX1 is activated, leading to the influx of Ca2+ into the cell, which may cause cell damage (PMID: 21289289, 30686898).

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