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N-p-trans-Coumaroyltyramine

N-p-trans-Coumaroyltyramine 是从蓼属植物中分离出的肉桂酰苯乙酰胺，是一种乙酰胆碱酯酶抑制剂，IC50 为 122 μM。它具有抗锥虫活性，对T. brucei rhodesiense 作用的 IC50值为 13.3 µM。

CAS号

36417-86-4

分子式

C17H17NO3

主要靶点

Parasite|AChE

仅限科研使用

Cat No : CM05888

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Synonyms

N-反式对香豆酰基酪胺|N-反式-对香豆酰酪胺

验证数据展示

  • CAS No.: 36417-86-4

    N-p-trans-Coumaroyltyramine
    CAS#: 36417-86-4

产品信息

N-p-trans-Coumaroyltyramine is a natural product, is an acetylcholinesterase (AChE) inhibitor with an an IC50 of 122 μM. N-p-trans-Coumaroyltyramine exhibits anti-trypanosomal activity with an IC50 of 13.3 μM for T. brucei rhodesiense.

CAS号 36417-86-4
分子式 C17H17NO3
主要靶点 Parasite|AChE
主要通路 微生物学|神经科学
分子量 283.33
纯度 99.56%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 N-反式对香豆酰基酪胺|N-反式-对香豆酰酪胺

靶点活性

AChE:122 μM

体外活性

The methanolic extract of the twigs of Celtis chinensis was found to show inhibitory activity on acetylcholinesterase (AChE), an enzyme that plays a role in the metabolic hydrolysis of ACh. Bioassay-guided fractionation of the methanolic extract resulted in the isolation of N-p-trans-Coumaroyltyramine, as an inhibitor on AChE[1]

溶解度

DMSO:27.5 mg/mL (97.06 mM)

参考文献

1.Inhibitory effect of trans-N-p-coumaroyl tryamine from the twigs of Celtis chinensis on the acetylcholinesterase.Arch. Pharm. Res.,2003, 26(9):735-8.

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