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Recombinant Mouse RAGE protein (His Tag)

种属

Mouse

纯度

>90 %, SDS-PAGE

标签

His Tag

生物活性

未测试

Cat no : Eg0873

Print datasheet

Synonyms

Ager, Advanced glycosylation end product-specific receptor, MOK, RAGE 1, RAGE1

验证数据展示

  • Purity of Recombinant Mouse RAGE was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse RAGE was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Mouse RAGE protein Gly23-Ala340 (Accession# Q62151-1) with a His tag at the C-terminus.
基因ID 11596
蛋白编号 Q62151-1
预测分子量 34.8 kDa
SDS-PAGE 37-45 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

RAGE (receptor for advanced glycation endproducts), also called AGER, is a transmembrane receptor of the immunoglobulin super family. It mediates interactions of advanced glycosylation end products (AGE) which accumulate in vascular tissue in aging in diabetes. Acts as a mediator of vascular inflammation such as atherosclerosis and a complication of diabetes. AGE/RAGE signal regulates production or expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation. Interaction with S100B after myocardial infarction regulates myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. ABPP-initiated RAGE signaling, especially stimulation of P38 mitogen-activated protein kinase (MAPK), delivers ABPP as a complex with RAGE to the intraneuronal. RAGE has higher expression in lung tissues, in particular in alveolar type I cells, and is lost in idiopathic pulmonary fibrosis (IPF).

参考文献:

1. Neeper M. et al. (1992) J Biol Chem. 267(21):14998-5004.
2. Hofmann MA. et al. (1999) Cell. 97(7):889-901.
3. Markus A. et al. (2008) Am J Respir Cell Mol Bio. 39(3):337-45.
4. Xue G. et al. (2008) Am J Physiol Heart Circ Physiol. 295(2):H491-8.
5. Takuma K. et al. (2009) Proc Natl Acad Sci U S A. 106(47):20021-6.
6. Fang F. et al. (2010) FASEB J. 24(4):1043-55.