Recombinant Mouse PDGF R alpha/PDGFRA protein (His Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
His Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <1.0 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse PDGF R alpha/PDGFRA protein Leu25-Ala528 (Accession# P26618-1) with a His tag at the C-terminus. |
| 基因ID | 18595 |
| 蛋白编号 | P26618-1 |
| 预测分子量 | 57.5 kDa |
| SDS-PAGE | |
| 组分 | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Platelet-derived growth factor receptor alpha (PDGFRA, also known as CD140a) is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. PDGFRA is implicated in the regulation of embryonic development, tumorigenesis, cell proliferation, survival, and chemotaxis. Mutations in the PDGFRA gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. PDGFRA and PDGFRB belong to receptor tyrosine kinase (RTK) family and function as receptors for platelet-derived growth factor (PDGF). PDGFRA is the only identified receptor to mediate PDGFA function in GBM.
参考文献:
1. Andrae J, et al. (2008) Genes Dev. 22(10):1276-312. 2. Ricci R, et al. (2015) Mod Pathol. 3. Gai QJ, et al. (2022). Signal Transduct Target Ther. 7(1):33.