Recombinant Mouse Myeloperoxidase protein (His Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
His Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <1.0 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse Myeloperoxidase protein Met16-Thr718(Accession# AAR99349) with a His tag at the C-terminus. |
| 基因ID | 17523 |
| 蛋白编号 | AAR99349 |
| 预测分子量 | 84 kDa |
| SDS-PAGE | |
| 组分 | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Myeloperoxidase (MPO) is a heme-containing enzyme primarily found in neutrophils and certain monocytes, playing a crucial role in the innate immune system. MPO generates reactive oxygen species (ROS), such as hypochlorous acid, which are essential for killing pathogens during phagocytosis. Additionally, MPO is a key component of neutrophil extracellular traps (NETs), which capture and kill extracellular pathogens. However, MPO can also contribute to tissue damage and inflammation when released from activated neutrophils. Elevated MPO levels have been associated with various diseases, including cardiovascular diseases and neurodegenerative disorders like Alzheimer's disease.
参考文献:
1. Wright, Joy R et al. Journal of Alzheimer's disease : JAD vol. 89,4 (2022): 1483-1492. 2. Aratani, Yasuaki. Archives of biochemistry and biophysics vol. 640 (2018): 47-52. 3. Strzepa, Anna et al. Cellular immunology vol. 317 (2017): 1-8. 4. Jannesar, Kosar, and Hamid Soraya. Biochemical and biophysical research communications vol. 755 (2025): 151578.