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Recombinant Mouse CSF1R protein (rFc Tag)

种属

Mouse

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg1816

Print datasheet

Synonyms

CD115, CSF 1R, CSF-1 receptor, Csfmr, EC:2.7.10.1

验证数据展示

  • Purity of Recombinant Mouse CSF1R was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse CSF1R was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Mouse CSF1R protein Ala20-Ser511 (Accession# P09581) with a rabbit IgG Fc tag at the C-terminus.
基因ID 12978
蛋白编号 P09581
预测分子量 81.5 kDa
SDS-PAGE 90-130kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

The CSF-1 receptor (CSF1R), also called CD115, is activated by the homodimeric growth factors colony-stimulating factor-1 (CSF-1) and interleukin-34 (IL-34). It plays important roles in development and in innate immunity by regulating the development of most tissue macrophages and osteoclasts, of Langerhans cells of the skin, of Paneth cells of the small intestine, and of brain microglia. It also regulates the differentiation of neural progenitor cells and controls functions of oocytes and trophoblastic cells in the female reproductive tract. Owing to this broad tissue expression pattern, it plays a central role in neoplastic, inflammatory, and neurological diseases.

参考文献:

1. E Richard Stanley, Violeta Chitu. (2014) Cold Spring Harb Perspect Biol. Jun 2;6(6):a021857.
2. Haishan Lin, et al. (2008) Science. May 9;320(5877):807-11.
3. David A Hume, Kelli P A MacDonald. (2012) Blood. Feb 23;119(8):1810-20.
4. Violeta Chitu, E Richard Stanley. (2006) Curr Opin Immunol. Feb;18(1):39-48.