Recombinant Mouse LAIR1 protein (His Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
His Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <1.0 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse LAIR1 protein Gln22-Tyr141 (Accession# Q8BG84-1) with a His tag at the C-terminus. |
| 基因ID | 52855 |
| 蛋白编号 | Q8BG84-1 |
| 预测分子量 | 14.6 kDa |
| SDS-PAGE | |
| 组分 | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR1 is expressed on the majority of human PBMCs, including NK, T, B, monocytes, and dendritic cells, as well as the majority of thymocytes. It functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of NK cells, B cells and T cells. LAIR1 is a collagen receptor. Tumor-expressed collagens can modulate immune cell function through the inhibitory collagen receptor LAIR1.
参考文献:
1. Meyaard, L et al. Immunity vol. 7,2 (1997): 283-90. 2. Meyaard, L et al. Journal of immunology (Baltimore, Md. : 1950) vol. 162,10 (1999): 5800-4. 3. Lebbink, Robert Jan et al. The Journal of experimental medicine vol. 203,6 (2006): 1419-25. 4. Rygiel, Tomasz P et al. Molecular immunology vol. 49,1-2 (2011): 402-6.