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Recombinant Mouse Ki67/MKI67 protein (rFc Tag)

种属

Mouse

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg1548

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Synonyms

验证数据展示

  • Purity of Recombinant Mouse MKI67 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse MKI67 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Mouse MKI67 protein Asp1816-Pro2163 (Accession# E9PVX6-1) with a rabbit IgG Fc tag at the N-terminus
基因ID 17345
蛋白编号 E9PVX6-1
预测分子量 65.5 kDa
SDS-PAGE 85-100 kDa, reducing (R) condition
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Ki67 is a nuclear protein encoded by the MKI67 gene, widely recognized as a marker for cell proliferation. It is expressed in all active phases of the cell cycle (G1, S, G2, and M) but absent in quiescent cells (G0). Initially identified by the monoclonal antibody Ki-67, its expression correlates with the growth fraction of tumor cells, making it a critical tool in oncology for assessing tumor aggressiveness and patient prognosis. Beyond proliferation, recent studies highlight Ki67's role in chromatin organization, ribosomal RNA transcription, and mitotic chromosome architecture, underscoring its multifunctionality in cellular processes.

参考文献:

1. Gerdes, J et al.Journal of immunology (Baltimore, Md. : 1950) vol. 133,4 (1984): 1710-5.
2. Luporsi, Elisabeth et al. Breast cancer research and treatment vol. 132,3 (2012): 895-915.
3. Scholzen, T, and J Gerdes. Journal of cellular physiology vol. 182,3 (2000): 311-22.
4. Aung, Thazin Nwe et al. Mod Pathol. Inc vol. 34,7 (2021): 1261-1270.