Recombinant Mouse IL-17C protein (rFc Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | CHO-derived Mouse IL-17C protein His15-Gln194 (Accession# Q8K4C5) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 234836 |
| 蛋白编号 | Q8K4C5 |
| 预测分子量 | 45.7 kDa |
| SDS-PAGE | 45-53 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
IL-17C is a member of the IL-17 cytokine family, was cloned from a human fetal kidney library in 2000 . The IL-17 family comprises at least 6 proinflammatory cytokines that share a conserved cystine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17C is selectively induced in epithelia by bacterial challenge and inflammatory stimuli . IL-17RE is a receptor specific to IL-17C and has an essential role in host mucosal defense against infection.
参考文献:
1.Chen, J et al. Proceedings of the National Academy of Sciences of the United States of America vol. 97,2 (2000): 773-8. 2.Kolls, Jay K et al. Immunity vol. 21,4 (2004): 467-76. 3.Hymowitz, S G et al. The EMBO journal vol. 20,19 (2001): 5332-41. 4.Ramirez-Carrozzi, Vladimir et al. Nature immunology vol. 12,12 (2011): 1159-66. 5.Shi, Peiqing et al. Nature immunology vol. 12,12 (2011): 1151-8.
