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Recombinant Mouse IGFBP2 protein (His Tag)

种属

Mouse

纯度

>90 %, SDS-PAGE

标签

His Tag

生物活性

未测试

Cat no : Eg1196

Print datasheet

Synonyms

IBP-2, IGF-binding protein 2, Igfbp2, IGFBP-2, Insulin-like growth factor-binding protein 2

验证数据展示

  • Purity of Recombinant Mouse IGFBP2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse IGFBP2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Mouse IGFBP2 protein Glu35-Gln305 (Accession# P47877) with a His tag at the C-terminus.
基因ID 16008
蛋白编号 P47877
预测分子量 30.6 kDa
SDS-PAGE 28-33 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

IGFBP2 is one of six homologous proteins in the IGFBP family. Based on its ability to bind IGFs with high affinity, IGFBP2 can exert its functions by interacting with IGFs in the circulation to control the function and activity of IGFs, and prevent the interaction between IGFs and IGF receptors.IGFBP2 was found to be highly expressed in many cancers, including glioma, lung cancer, colorectal cancer, ovarian cancer (OC), rhabdomyosarcoma, gastric cancer, breast cancer, bladder cancer, prostate cancer, endometrial cancer, penile squamous cell carcinoma, and hepatocellular carcinoma.

参考文献:

1. Perez-Larraya JG. et al. (2014). Cancer.120(24):3972-3980.
2.Yuan Q.et al. (2019). Biosci Rep. 39(6):387-395.
3. Han S.et al. (2014). PLoS One. 9(4):e93791.
4. Lin Y.et al. (2009). Neuro Oncol. 11(5):468-476
5.Guo C.et al. (2013). PLoS One. 8(9):202-206.