Recombinant Mouse Ctsb protein (rFc Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <1.0 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse Ctsb protein His18-Phe339 (Accession# P10605) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 13030 |
| 蛋白编号 | P10605 |
| 预测分子量 | 60.9 kDa |
| SDS-PAGE | |
| 组分 | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
CTSB (cathepsin B), a member of the cysteine cathepsin family. was primarily found as a cysteine protease that was involved in the degradation of lysosomal proteins. Cathepsin B is secreted as a pro-enzyme and is activated to its active form via various molecules.Cathepsin B was identified as the major enzyme responsible for endosomal proteolysis of internalized epidermal growth factor receptor complexes and insulin-like growth factor-I. Cathepsin B also degrades preformed extracellular oligomeric and fibrillar amyloid in aged APP transgenic mice.
参考文献:
1. Gondi, Christopher S, and Jasti S Rao. Expert opinion on therapeutic targets vol. 17,3 (2013): 281-91. 2. Wang, Chao et al. The Journal of biological chemistry vol. 287,47 (2012): 39834-41. 3. Guicciardi, M E et al. The American journal of pathology vol. 159,6 (2001): 2045-54. 4. Stahl, Sonja et al. Biochimica et biophysica acta vol. 1774,10 (2007): 1237-46.