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Recombinant Mouse Coagulation factor II/F2 protein (His Tag)

种属

Mouse

纯度

>90 %, SDS-PAGE

标签

His Tag

生物活性

未测试

Cat no : Eg0943

Print datasheet

Synonyms

Coagulation factor II, F2, Prothrombin, Activation peptide fragment 1, Activation peptide fragment 2

验证数据展示

  • Purity of Recombinant Mouse Coagulation factor II was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse Coagulation factor II was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Mouse Coagulation factor II protein Gln25-Gly618 (Accession# P19221) with a His tag at the C-terminus.
基因ID 14061
蛋白编号 P19221
预测分子量 69.0 kDa
SDS-PAGE 65-80 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Normal blood coagulation is a complex process, involving a cascade of activation of different plasma proteins, ultimately resulting in the formation of a clot, called fibrin. Coagulation Factor II (F2), also known as prothrombin or factor II, is one of the components of this chain of plasma proteins involved in blood coagulation. Prothrombin is the precursor of thrombin, which is essential in the processes of hemostasis and thrombosis. Prothrombin circulates in the bloodstream in an inactive form until an injury occurs. In response to that, prothrombin is converted to its active form, thrombin. Thrombin next converts a protein called fibrinogen into fibrin. Thrombin is also important for cell growth and division, tissue repair, and new blood vessel formation - angiogenesis.

参考文献:

1. Akhavan S, et al. (2000). Thromb Haemost. 84(6):989-97.
2. Danckwardt S, et al.(2006). Acta Haematol.115(3-4):192-7.
3.Jayandharan G, et al.(2005). Journal of thrombosis and hemostasis. 3(7):1446-53.
4.McGlennen RC, et al. (2002). Arch Pathol Lab Med.126(11):1319-25.