Recombinant Mouse PTGFRN/CD315 protein (C-rFc)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse PTGFRN protein Arg22-Pro832 (Accession# Q9WV91) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 19221 |
| 蛋白编号 | Q9WV91 |
| 预测分子量 | 117.7 kDa |
| SDS-PAGE | 120-150 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
PTGFRN (Prostaglandin F2 Receptor Negative Regulator), also known as CD315, is a trans-membrane protein that modulates prostaglandin F2α signaling and links the tetraspanin web to the cytoskeleton, it is now recognized as a driver of metastasis; high expression correlates with aggressive proliferation, migration, and spheroid growth in epidermoid carcinoma, medulloblastoma, and mesothelioma, while silencing PTGFRN impairs these traits and disrupts autophagy.
参考文献:
1.Orlicky, D J et al. Human genetics vol. 97,5 (1996): 655-8. 2.Aguila, Brittany et al. Cancer letters vol. 462 (2019): 33-42. 3.Marquez, Jorge et al. Journal of cellular biochemistry vol. 125,8 (2024): e30616.
