Recombinant Mouse CD28 protein (rFc Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <1.0 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse CD28 protein Asn20-Leu150 (Accession# P31041) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 12487 |
| 蛋白编号 | P31041 |
| 预测分子量 | 41.4 kDa |
| SDS-PAGE | |
| 组分 | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
CD28 (T-cell-specific surface glycoprotein CD28), also known as T44 and Tp44, is a 44 kD disulfide-linked homodimeric type I glycoprotein. It is a member of the immunoglobulin superfamily and is expressed on most T lineage cells, NK cell subsets, and plasma cells. CD28 may affect in vivo immune responses by functioning both as a cell adhesion molecule linking B and T lymphocytes and as the surface component of a novel signal transduction pathway. CD28 binds both CD80 and CD86 with a highly conserved motif MYPPY in the CDR3-like loop. CD28 is considered a major co-stimulatory molecule, inducing T lymphocyte activation and IL-2 synthesis, and preventing cell death.
参考文献:
1. June, C H et al. Immunology today vol. 11,6 (1990): 211-6. 2. Linsley, P S, and J A Ledbetter. Annual review of immunology vol. 11 (1993): 191-212. 3. Lesslauer, W et al. European journal of immunology vol. 16,10 (1986): 1289-96. 4. Evans, Edward J et al. Nature immunology vol. 6,3 (2005): 271-9. 5. Peach, R J et al. The Journal of experimental medicine vol. 180,6 (1994): 2049-58. 6. Williams, T M et al. Journal of immunology (Baltimore, Md. : 1950) vol. 148,8 (1992): 2609-16.