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Molidustat

Molidustat (BAY 85-3934) 是新型HIF-PH 抑制剂，对PHD1(IC50:480 nM)、PHD2(IC50:280 nM)、PHD3(IC50:450 nM)。

CAS号

1154028-82-6

分子式

C13H14N8O2

主要靶点

HIF/HIF Prolyl-Hydroxylase

仅限科研使用

Cat No : CM11470

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Synonyms

BAY 85-3934

验证数据展示

  • CAS No.: 1154028-82-6

    Molidustat
    CAS#: 1154028-82-6

产品信息

Molidustat(BAY-85-3934), an inhibitor of hypoxia-inducible factor (HIF) prolyl hydroxylase (PH), stimulates erythropoietin (EPO) production and the formation of red blood cells.

CAS号 1154028-82-6
分子式 C13H14N8O2
主要靶点 HIF/HIF Prolyl-Hydroxylase
主要通路 代谢|表观遗传
分子量 314.3
纯度 99.71%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 BAY 85-3934

靶点活性

PHD2:280 nM|PHD3:450 nM|PHD1:480 nM

体内活性

In healthy Wistar rats and cynomolgus monkeys, Molidustat (1.5 mg/kg, p.o.) induces dose-dependent production of EPO and erythropoiesis. In rats with gentamicin-induced renal anemiabe, Molidustat (5 mg/kg, p.o.) is also effective in raising hematocrit levels while stimulating endogenous EPO production without hypertensive effects. [1]

体外活性

In vitro, Molidustat induces the transcription of hypoxia-sensitive genes in HeLa, A549, and Hep3B cells. [1]

溶解度

DMSO:11 mg/mL (35 mM),Sonification is recommended.

参考文献

1.Flamme I, et al. PLoS One. 2014, 9(11):e111838.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2