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Mirogabalin

CAS号

1138245-13-2

分子式

C12H19NO2

主要靶点

Calcium Channel

仅限科研使用

Cat No : CM03240

Print datasheet

Synonyms

DS 5565|DS5565|DS-5565|inhibit|CalciumChannel|Calcium Channel|Ca channels|Ca2+ channels|Inhibitor|Mirogabalin|α2δ calcium channels

验证数据展示

  • CAS No.: 1138245-13-2

    Mirogabalin
    CAS#: 1138245-13-2

产品信息

CAS号 1138245-13-2
分子式 C12H19NO2
主要靶点 Calcium Channel
主要通路 离子通道|代谢
分子量 209.28
纯度 99.89%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 DS 5565|DS5565|DS-5565|inhibit|CalciumChannel|Calcium Channel|Ca channels|Ca2+ channels|Inhibitor|Mirogabalin|α2δ calcium channels

体内活性

Mirogabalin在通过链脲佐菌素诱导的糖尿病大鼠中表现出强效且持久的镇痛效果（ED50 = 2.5 mg/kg）。在其有效剂量下，Mirogabalin不会抑制与镇痛剂相关的中枢神经系统不良反应活动，如旋转木马表现（ID50 = 9.4 mg/kg）或运动能力（ID50 = 43.9 mg/kg）。

溶解度

DMSO:1.83 mg/mL (8.76 mM)

参考文献

1.Vinik A , Rosenstock J , Sharma U , et al. Efficacy and Safety of Mirogabalin (DS-5565) for the Treatment of Diabetic Peripheral Neuropathic Pain: A Randomized, Double-Blind, Placebo- and Active Comparator-Controlled, Adaptive Proof-of-Concept Phase 2 Study[J]. Diabetes Care, 2014, 37(12):3253-61.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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C1   V1   C2   V2